Kathiresan S, Voight BF, Purcell S, Musunuru K, et al. PMID: 19198609 (cited by 480). This is among the first published genome-wide association studies for the early-onset myocardial infarction (MI) phenotype.  We demonstrated that common DNA sequence variants at nine gene regions contribute to risk for MI, the leading cause of death in the U.S. … Read more

Kathiresan S, Melander O, Roos C, Guiducci C, Burtt NP, Anevski D, Hirschhorn, JN, Berglund G, Hedblad B, Groop L, Altshuler DM, Newton-Cheh C, Orho-Melander, M. PMID: 18354102 (cited by 400). This study is among the first to empirically validate the concept of a genetic risk score.  We provided proof-of-concept that the additive combination of multiple … Read more

Musunuru K*, Pirruccello JP*, Do R*, Peloso GM, Guiducci C, Sougnez C, Garimella KV, Fisher S, Abreu J, Barry AJ, Fennell T, Banks E, Ambrogio L, Cibulskis K, Kernytsky A, Gonzalez E, Rudzicz N, Engert JC, DePristo MA, Daly MJ, Cohen JC, Hobbs HH, Altshuler D, Schonfeld G, Gabriel SB*, Yue P*, Kathiresan S*. PMID: 20942659 … Read more

Teslovich TM, Musunuru K*, Smith AV, Edmondson AC, Stylianou IM, Koseki M, Pirruccello JP, Ripatti S, Chasman DI, Willer CJ, Johansen CT, Fouchier SW, Isaacs A, Peloso GM, Barbalic M, Ricketts SL, Bis JC, Aulchenko YS, Thorleifsson G, Feitosa MF, Chambers J, Orho-Melander M, Melander O, Johnson T, Li X, Guo X, Li M, Shin … Read more

Voight BF, Peloso GM*, Orho-Melander M, Frikke-Schmidt R, Barbalic M, Jensen MK, Hindy G, Holm H, Ding EL, Johnson T, Schunkert H, Samani NJ, Clarke R, Hopewell JC, Thompson JF, Li M, Thorleifsson G, Newton-Cheh C, Musunuru K, Pirruccello JP, Saleheen D, Chen L, Stewart A, Schillert A, Thorsteinsdottir U, Thorgeirsson G, Anand S, Engert … Read more

Do R*, Willer CJ, Schmidt EM, Sengupta S, Global Lipids Genetics Consortium, Daly MJ, Neale BM, and Kathiresan S. PMID: 24097064 (cited by 12). Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it has been hotly debated as to … Read more

Crosby J*, Peloso GM,* Auer PL*, TG and HDL Working Group of the Exome Sequencing Project, National, Heart, Lung, and Blood Institute, Reiner AP*, Boerwinkle E*, Kathiresan S*. In a large-scale population-based exome sequencing study for plasma lipids, we discovered that people who carry rare mutations that reduce the production of the APOC3 protein have very low levels … Read more

Myocardial Infarction Genetics Consortium Investigators, Stitziel NO, Won HH, Morrison AC, Peloso GM, Do R, Lange LA, Fontanillas P, Gupta N, Duga S, Goel A, Farrall M, Saleheen D, Ferrario P, König I, Asselta R, Merlini PA, Marziliano N, Notarangelo MF, Schick U, Auer P, Assimes TL, Reilly M, Wilensky R, Rader DJ, Hovingh GK, … Read more

Amit V. Khera, MD, Hong-Hee Won, PhD, Gina M. Peloso, PhD, Kim S. Lawson, MS, Traci M. Bartz, MS, Xuan Deng, MSc, Elisabeth M. van Leeuwen, Pradeep Natarajan, MD, MMSc, Connor A. Emdin, HBSc, Alexander G. Bick, BS, Alanna C. Morrison, PhD, Jennifer A. Brody, BA, Namrata Gupta, PhD, Akihiro Nomura, MD, Thorsten Kessler, MD, … Read more

Stitziel NO, Stirrups KE, Masca NG, Erdmann J, Ferrario PG, König IR, Weeke PE, Webb TR, Auer PL, Schick UM, Lu Y, Zhang H, Dube MP, Goel A, Farrall M, Peloso GM, Won HH, Do R, van Iperen E, Kanoni S, Kruppa J, Mahajan A, Scott RA, Willenborg C, Braund PS, van Capelleveen JC, Doney … Read more