Polygenic Risk Score Identifies Subgroup with Higher Burden of Atherosclerosis and Greater Relative Benefit from Statin Therapy in the Primary Prevention Setting

Natarajan P, Young R, Stitziel NO, Padmanabhan S, Baber U, Mehran R, Sartori S, Fuster V, Reilly DF, Butterworth AS, Rader DJ, Ford I, Sattar N, Kathiresan S.

The present study had two main goals: first, to test in a third statin trial if statin treatment confers a greater relative risk reduction for a first coronary event in those at high genetic risk, as assessed by an expanded 57-SNP polygenic risk score, compared to all others; second, to test if there is a greater burden of subclinical coronary atherosclerosis present in those at high genetic risk compared to all others.

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