Polymorphisms associated with cholesterol and risk of cardiovascular events

Kathiresan S, Melander O, Roos C, Guiducci C, Burtt NP, Anevski D, Hirschhorn, JN, Berglund G, Hedblad B, Groop L, Altshuler DM, Newton-Cheh C, Orho-Melander, M. PMID: 18354102 (cited by 400).

This study is among the first to empirically validate the concept of a genetic risk score.  We provided proof-of-concept that the additive combination of multiple common variants, as a genetic risk score, can contribute to risk for cardiovascular disease.

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