Polymorphisms associated with cholesterol and risk of cardiovascular events. N Engl J Med 2008;358: 1240-1249.

Kathiresan S, Melander O, Roos C, Guiducci C, Burtt NP, Anevski D, Hirschhorn, JN, Berglund G, Hedblad B, Groop L, Altshuler DM, Newton-Cheh C, Orho-Melander, M. PMID: 18354102 (cited by 400).

This study is among the first to empirically validate the concept of a genetic risk score.  We provided proof-of-concept that the additive combination of multiple common variants, as a genetic risk score, can contribute to risk for cardiovascular disease.

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