Genetic factors contribute to inter-individual differences in risk for myocardial infarction and risk factors such as blood LDL cholesterol and triglycerides. We are using both family-based and population-based study designs as well genotyping and sequencing approaches to pinpoint the specific nucleotides in our DNA sequence responsible for such inter-individual differences.
Here are some of the questions we are working to answer:
Are there any genes that protect people from risk for heart attack?
Which genes contribute to variation in plasma cholesterol and triglyceride levels in the population?
Which genes cause heart attack and do any of these operate outside of known risk factors for heart disease?
How does one discover a gene responsible for heart attack risk?